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(Photo by Kira Evitts)

(Photo by Kira Evitts)

Our Research Projects

Our research focuses on the molecular mechanisms behind Alzheimer’s disease pathogenesis with the hope that our work will lead to effective AD therapies.  


We generate neurons, glia, and brain organoid from human induced pluripotent stem cell models to study:

  • How dysfunction in endo-lysosomal pathways contribute to AD risk.

  • How alterations in expression of epigentic regulators affect mitochondrial function in AD.

  • How neurovascular cues influence AD cellular phenotypes.

  • How commonly used medication in the elderly may impact neuronal health (collaboration with the Seattle ACT study).

  • How to dissect sex differences and APOE genotypes in AD risk.



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Research Affiliations

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