Our research focuses on the molecular mechanisms behind Alzheimer’s disease pathogenesis with the hope that our work will lead to effective AD therapies.  

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We generate neurons, glia, and brain organoid from human induced pluripotent stem cell models to study:

• How dysfunction in endo-lysosomal pathways contribute cell stress, synapse dysfunction and neuronal hyperexcitability, and overall risk for Alzheimer's disease

• How alterations in genes linked to aging affect proteostasis and mitochondrial function in our cell models

• How neurovascular cues influence AD cellular phenotypes.

• How commonly used medication in the elderly may impact neuronal health (collaboration with the Seattle ACT study).

• How to dissect sex differences and APOE genotypes in AD risk.